Name | 2,3,4-trimethoxybenzyl alcohol |
Synonyms | RARECHEM AL BD 0024 TriMetazidine EP IMpurity-D 2,3,4-TRIMETHOXYBENZYL ALCOHOL 2,3,4-trimethoxybenzyl alcohol 2,3,4-Trimethoxybenzenemethanol 2,3,4-Trimethoxybenzene methanol (2,3,4-Trimethoxyphenyl)methanol Benzyl alcohol, 2,3,4-trimethoxy- Benzenemethanol, 2,3,4-trimethoxy- |
CAS | 71989-96-3 |
EINECS | 276-270-0 |
InChI | InChI=1/C10H14O4/c1-12-8-5-4-7(6-11)9(13-2)10(8)14-3/h4-5,11H,6H2,1-3H3 |
Molecular Formula | C10H14O4 |
Molar Mass | 198.22 |
Density | 1.151 g/mL at 25 °C (lit.) |
Boling Point | 105 °C/25 mmHg (lit.) |
Flash Point | >230°F |
Solubility | Chloroform, Methanol |
Vapor Presure | 0.000251mmHg at 25°C |
Appearance | Oil |
Color | Clear Colourless to Pale Yellow |
pKa | 13.92±0.10(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | n20/D 1.532(lit.) |
MDL | MFCD00004613 |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
HS Code | 29094990 |
Hazard Class | IRRITANT |
Application | impurity research is an important content of drug research and development. It includes the selection of appropriate analytical methods, accurate discrimination and determination of impurity content and comprehensive pharmaceutical, toxicological and clinical research results to determine the reasonable limit of impurities. This research runs through the entire process of drug development. Due to the drug in the clinical use of adverse reactions in addition to the pharmacological activity of the drug itself, but also related to the impurities in the drug. For example, high molecular weight impurities such as polymers in antibiotics such as penicillin are the main cause of allergy. Therefore, the study of impurities in a standardized way and the control of impurities in a safe and reasonable range will be directly related to the quality and safety of drugs on the market. Trimetazidine impurity D can be used in the development of trimetazidine in the development process of the standard, it is necessary to conduct a detailed study on the quality of the same variety of products that have been listed, analyze the types of impurities including trimetazidine impurity D and its content, and make a comprehensive quality comparison with the products under study, according to this, the impurity limit of the product, including the limit of trimetazidine impurity D, is further developed. |